Optimization of surgical intervention outside the epileptogenic zone in the Virtual Epileptic Patient (VEP).

ABSTRACT: Studies to improve the efficacy of epilepsy surgery have focused on better refining the localization of the epileptogenic zone (EZ) with the aim of effectively resecting it. However, in a considerable number of patients, EZs are distributed across multiple brain regions and may involve eloquent areas that cannot be removed due to the risk of neurological complications. There is a clear need for developing alternative approaches to induce seizure relief, but minimal impact on normal brain functions. Here, we develop a personalized in-silico network approach, that suggests effective and safe surgical interventions for each patient. Based on the clinically identified EZ, we employ modularity analysis to identify target brain regions and fiber tracts involved in seizure propagation. We then co

SUBMITTER: An S 

PROVIDER: S-EPMC6594587 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature