Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships.

ABSTRACT: Infections with human herpesviruses are ubiquitous and a public health concern worldwide. Current treatments reduce the severity of some symptoms associated to herpetic infections but neither remove the viral reservoir from the infected host nor protect from the recurrent symptom outbreaks that characterise herpetic infections. The difficulty in therapeutically tackling these viral systems stems in part from their remarkably large proteomes and the complex networks of physical and functional associations that they tailor. This study presents our efforts to unravel the complexity of the interactome of herpes simplex virus type 1 (HSV1), the prototypical herpesvirus species. Inspired by our previous work, we present an improved and more integrative computational pipeline for the protein-prot

SUBMITTER: Hernandez Duran A 

PROVIDER: S-EPMC6594648 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature