New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors.

ABSTRACT: Megakaryocytes are hematopoietic cells, which are responsible for the production of blood platelets. The traditional view of megakaryopoiesis describes the cellular journey from hematopoietic stem cells, through a hierarchical series of progenitor cells, ultimately to a mature megakaryocyte. Once mature, the megakaryocyte then undergoes a terminal maturation process involving multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation. However, recent studies have begun to redefine this hierarchy and shed new light on alternative routes by which hematopoietic stem cells are differentiated into megakaryocytes. In particular, the origin of megakaryocytes, including the existence and hierarchy of megakaryocyte progenitors, has been redefined, as new studies are su

SUBMITTER: Noetzli LJ 

PROVIDER: S-EPMC6594866 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature