Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment.

ABSTRACT: BACKGROUND:Childhood maltreatment is one of the most potent predictors of future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in the pathogenesis and maintenance of internalizing disorders among individuals with a history of childhood maltreatment. METHODS:Using data from a sample of 1,144 young adults, we investigated the contribution of baseline threat-related amygdala reactivity and prospective major stressful life events to internalizing symptoms severity 1 year later (on average) in individuals with a history of maltreatment (n = 100) and propensity score matched nonmaltreated peers (n = 96). RESULTS:Even after stringently matching for several potentially confoundi

SUBMITTER: Gerin MI 

PROVIDER: S-EPMC6594878 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature