Adult Pgf^-/- mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor.

ABSTRACT: Offspring of preeclamptic pregnancies have cognitive alterations. Placental growth factor (PGF), is low in preeclampsia; reduced levels may affect brain development. PGF-null mice differ from normal congenic controls in cerebrovasculature, neuroanatomy and behavior. Using brain imaging and behavioral testing, we asked whether developmentally asynchronous (i.e. neonatal) PGF supplementation alters the vascular, neuroanatomic and/or behavioral status of Pgf^-/- mice at adulthood. C57BL/6-Pgf^-/- pups were treated intraperitoneally on postnatal days 1-10 with vehicle or PGF at 10 pg/g, 70 pg/g or 700 pg/g. These mice underwent behavioral testing and perfusion for MRI and analysis of retinal vasculature. A second cohort of vehicle- or PGF-treated mice was perfused for micro

SUBMITTER: Kay VR 

PROVIDER: S-EPMC6594955 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature