Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials.

ABSTRACT:

Background

The duration of protection offered by rotavirus vaccines varies across the world, and this variation is important to understanding and predicting the effects of the vaccines. There is now a large body of evidence on the efficacy of live oral rotavirus vaccines in different settings, but these data have never been synthesised to obtain robust estimates of efficacy by duration of follow-up. Our aim is to estimate the efficacy of live oral rotavirus vaccines at each point during follow-up and by mortality stratum.

Methods

In our meta-regression study, we identified all randomised controlled trials of rotavirus vaccines published until April 4, 2018, using the results of a Cochrane systematic review, and cross checked these studies against those identified by another

SUBMITTER: Clark A 

PROVIDER: S-EPMC6595176 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature