Genetic diversity and drug resistance of Mycobacterium tuberculosis in Yunnan, China.

ABSTRACT:

Background

China is a country with high burden of tuberculosis (TB), especially drug-resistant TB (DR-TB), which is still a serious health problem in Yunnan Province. Mycobacterium tuberculosis (MTB) is the pathogenic microorganism of TB. The epidemiological characteristics of MTB strains in local areas need to be described.

Methods

A total of 430 clinical MTB isolates were collected from Yunnan Province and genotyped through the method of 24-locus mycobacterial interspersed repetitive unit-variable number tandem DNA repeats (MIRU-VNTR).

Results

The genotypes of the 24 loci showed abundantly genetic diversity, and allelic diversity index (h) of these loci varied from 0.012 to 0.817. Among the 430 strains, 30 clusters and 370 unique genotypes were identified. Beijing f

SUBMITTER: Li D 

PROVIDER: S-EPMC6595362 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature