Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.

ABSTRACT: An elevated low-density lipoprotein cholesterol concentration is a classical risk factor for cardiovascular disease. This has led to pharmacotherapy in patients with atherosclerotic heart disease or high heart disease risk with statins to reduce serum low-density lipoprotein cholesterol. Even in patients in whom the target levels of low-density lipoprotein cholesterol are reached, there remains a significant residual cardiovascular risk; this is due, in part, to a focus on low-density lipoprotein cholesterol alone and neglect of other important aspects of lipoprotein metabolism. A more refined lipoprotein analysis will provide additional information on the accumulation of very low-density lipoproteins, intermediate density lipoproteins, chylomicrons, chylomicron-remnants and Lp(a) concentr

SUBMITTER: Renee Ruhaak L 

PROVIDER: S-EPMC6595551 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature