Changes in Centrality Frequency of the Default Mode Network in Individuals With Subjective Cognitive Decline.

ABSTRACT: Despite subjective cognitive decline (SCD), a preclinical stage of Alzheimer's disease (AD), being widely studied in recent years, studies on centrality frequency in individuals with SCD are lacking. This study aimed to investigate the differences in centrality frequency between individuals with SCD and normal controls (NCs). Forty individuals with SCD and 53 well-matched NCs underwent a resting-state functional magnetic resonance imaging scan. We assessed individual dynamic functional connectivity using sliding window correlations. In each time window, brain regions with a high degree centrality were defined as hubs. Across the entire time window, the proportion of time that the hub appeared was characterized as centrality frequency. The centrality frequency correlated with cognitive perf

SUBMITTER: Xie Y 

PROVIDER: S-EPMC6595963 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature