Congenital Cytomegalovirus Infection Alters Olfaction Before Hearing Deterioration In Mice.

ABSTRACT: In developed countries, cytomegalovirus (CMV)-infected newborns are at high risk of developing sensorineural handicaps such as hearing loss, requiring extensive follow-up. However, early prognostic tools for auditory damage in children are not yet available. In the fetus, CMV infection leads to early olfactory bulb (OB) damage, suggesting that olfaction might represent a valuable prognosis for neurological outcome of this viral infection. Here, we demonstrate that in utero CMV inoculation causes fetal infection and growth retardation in mice of both sexes. It disrupts OB normal development, leading to disproportionate OB cell layers and rapid major olfactory deficits. Olfaction is impaired as early as day 6 after birth in both sexes, long before the emergence of auditory deficits. O

SUBMITTER: Lazarini F 

PROVIDER: S-EPMC6596252 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature