The impact of leukapheresis on immune-cell number and function in patients with advanced cancer.

ABSTRACT:

Background

Leukapheresis is often performed in cancer patients to harvest stem cells, manufacture therapeutic vaccines, or follow immunologic response to therapy. We have recently described the minimal impact of leukapheresis on normal donors. Here we provide additional immunologic data from patients with advanced cancer who underwent leukapheresis.

Methods

Using data from cancer patients on clinical trials who had leukapheresis (n = 64) or peripheral blood draws only (n = 90) as controls for immune analysis, we evaluated the impact of leukapheresis on number and function of lymphocytes.

Results

In the leukapheresis group, median age was 63.5 (range 38-82); 87.5 % were male. Comparing pre- and post-leukapheresis values within the groups, with each patient as its own c

SUBMITTER: Gulley JL 

PROVIDER: S-EPMC6596285 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature