Unequivocal determination of complex molecular structures using anisotropic NMR measurements.

ABSTRACT: Assignment of complex molecular structures from nuclear magnetic resonance (NMR) data can be prone to interpretational mistakes. Residual dipolar couplings and residual chemical shift anisotropy provide a spatial view of the relative orientations between bonds and chemical shielding tensors, respectively, regardless of separation. Consequently, these data constitute a reliable reporter of global structural validity. Anisotropic NMR parameters can be used to evaluate investigators' structure proposals or structures generated by computer-assisted structure elucidation. Application of the method to several complex structure assignment problems shows promising results that signal a potential paradigm shift from conventional NMR data interpretation, which may be of particular utility for compou

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6596297 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature