Association of Prepubertal and Postpubertal Exposure to Childhood Maltreatment With Adult Amygdala Function.

ABSTRACT:

Importance

Abnormalities in amygdala response to threatening faces have been observed in anxiety disorders, autism, bipolar disorder, depression, posttraumatic stress disorder, and schizophrenia. Abnormally hyperactive and hypoactive responses have typically been associated with anxiety and inhibition vs risk taking and inappropriate social behaviors. Maltreatment is a major risk factor for most of these disorders and is associated with abnormal amygdala function.

Objective

To identify the type and age of exposure to childhood maltreatment that are associated with hyperactive and hypoactive amygdala responses in young adulthood.

Design, setting, and participants

Data collection for this retrospective cohort study took place from November 8, 2010, to August 23, 2012. D

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6596335 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature