Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth.

ABSTRACT:

Background

Preterm birth (PTB) is a major cause of neonatal mortality and morbidity. There is strong evidence of genetic susceptibility. Objective of this study was to identify genetic variants contributing to PTB.

Methods

Genotyping was performed for 24 single nucleotide polymorphisms (SNPs) in 4 candidate genes (NR5A2, FSHR, FOXP3, and SERPINH1). Genotyping was completed on 728 maternal triads (mother and maternal grandparents of a preterm infant). Data were analyzed with Family Based Association Test.

Results

For all maternal triads rs2737667 of NR5A2 showed significant association at P = 0.02. When stratifying by gestational age three SNPs in NR5A2 had P values <0.05 in the <32-wk gestational age group (rs12131233, P = 0.007; rs2737667, P = 0.04; rs2816949, P = 0.

SUBMITTER: Kaluarachchi DC 

PROVIDER: S-EPMC6596415 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature