Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing.

ABSTRACT: The human retina is a complex tissue responsible for detecting photons of light and converting information from these photons into the neurochemical signals interpreted as vision. Such visual signaling not only requires sophisticated interactions between multiple classes of neurons, but also spatially-dependent molecular specialization of individual cell types. In this study, we performed single-cell RNA sequencing on neural retina isolated from both the fovea and peripheral retina in three human donors. We recovered a total of 8,217 cells, with 3,578 cells originating from the fovea and 4,639 cells originating from the periphery. Expression profiles for all major retinal cell types were compiled, and differential expression analysis was performed between cells of foveal versus peripheral

SUBMITTER: Voigt AP 

PROVIDER: S-EPMC6596422 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature