Structures, Spectroscopic Properties, and Dioxygen Reactivity of 5- and 6-Coordinate Nonheme Iron(II) Complexes: A Combined Enzyme/Model Study of Thiol Dioxygenases.

ABSTRACT: The synthesis of four new Fe^II(N₄S(thiolate)) complexes as models of the thiol dioxygenases are described. They are composed of derivatives of the neutral, tridentate ligand triazacyclononane (R₃TACN; R = Me, iPr) and 2-aminobenzenethiolate (abt^x; X = H, CF₃), a non-native substrate for thiol dioxygenases. The coordination number of these complexes depends on the identity of the TACN derivative, giving 6-coordinate (6-coord) complexes for Fe^II(Me₃TACN)(abt^x)(OTf) (1: X = H; 2: X = CF₃) and 5-coordinate (5-coord) complexes for [Fe^II(iPr₃TACN)(abt^x)](OTf) (3: X = H; 4: X = CF₃). Complexes 1-4 were examined by UV-vis, ¹H/¹⁹F NMR,

SUBMITTER: Gordon JB 

PROVIDER: S-EPMC6596423 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature