Role of the Excitability Brake Potassium Current I_KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury.

ABSTRACT: Cold allodynia is a common symptom of neuropathic and inflammatory pain following peripheral nerve injury. The mechanisms underlying this disabling sensory alteration are not entirely understood. In primary somatosensory neurons, cold sensitivity is mainly determined by a functional counterbalance between cold-activated TRPM8 channels and Shaker-like Kv1.1-1.2 channels underlying the excitability brake current I_KD Here we studied the role of I_KD in damage-triggered painful hypersensitivity to innocuous cold. We found that cold allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in mice, was related to both an increase in the proportion of cold-sensitive neurons (CSNs) in DRGs contributing to the sciatic nerve, and a decrease in their cold tempe

SUBMITTER: Gonzalez A 

PROVIDER: S-EPMC6596778 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature