4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia.

ABSTRACT:

Background

Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets in the development of sarcopenia is poorly understood. Eukaryotic initiation factor 4E-binding proteins (4E-BPs) are targets of mTOR that repress mRNA translation initiation and are involved in the control of several physiological processes. However, their role in skeletal muscle is still poorly understood. The goal of this study was to assess how loss of 4E-BP1 and 4E-BP2 expression impacts skeletal muscle function and homeostasis in aged mice and to characterize the associated metabolic changes by metabolomic and lipidomic profiling.

SUBMITTER: Le Bacquer O 

PROVIDER: S-EPMC6596930 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature