A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.

ABSTRACT: Nucleic acids from bacteria or viruses induce potent immune responses in infected cells^1-4. The detection of pathogen-derived nucleic acids is a central strategy by which the host senses infection and initiates protective immune responses^5,6. Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor^7,8. It catalyses the synthesis of cyclic GMP-AMP (cGAMP)^9-12, which stimulates the induction of type I interferons through the STING-TBK1-IRF-3 signalling axis^13-15. STING oligomerizes after binding of cGAMP, leading to the recruitment and activation of the TBK1 kinase^8,16. The IRF-3 transcription factor is then recruited to the signalling complex and activated by TBK1^8,17-20. Phosphorylated IRF-3 translocates to

SUBMITTER: Zhao B 

PROVIDER: S-EPMC6596994 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature