Systematic review of the performance and clinical utility of point of care HIV-1 RNA testing for diagnosis and care.

ABSTRACT:

Background

Point of-care (POC) HIV-1 RNA tests which are accurate and easy to use with limited infrastructure are needed in resource-limited settings (RLS). We systematically reviewed evidence of POC test performance compared to laboratory-based HIV-1 RNA assays and the potential utility of these tests for diagnosis and care in RLS.

Methods

Studies published up to July 2018 were identified by a search of PUBMED, EMBASE, Web of Science, CINAHL and Cochrane Central Register of Controlled Trials. Studies evaluating the use of POC HIV-1 RNA testing for early infant diagnosis (EID), acute HIV infection (AHI) diagnosis, or viral load monitoring (VL), compared to centralized testing, were included. Separate search strategies were used for each testing objective.

Results

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SUBMITTER: Agutu CA 

PROVIDER: S-EPMC6597060 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature