The Role of Ca_V2.1 Channel Facilitation in Synaptic Facilitation.

ABSTRACT: Activation of Ca_V2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated Ca_V2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that, under conditions of physiological calcium and near-physiological temperatures, synaptic facilitation at hippocampal CA3 to CA1 synapses was not attenuated in Ca IM-AA mice and facilitation was paradoxically more prominent at two cerebellar synapses. Enhanced facilitation at these synapses is consistent with a decrease in initial calcium entry, suggested by an action-potential-evoked Ca_V2.1 current reduction in Purkinje cells from Ca IM-AA mice. In wild-type mice, Ca<

SUBMITTER: Weyrer C 

PROVIDER: S-EPMC6597251 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature