Neural mechanisms of face emotion processing in youths and adults with bipolar disorder.

ABSTRACT:

Objectives

Little is known about potential differences in the pathophysiology of bipolar disorder (BD) across development. The present study aimed to characterize age-related neural mechanisms of BD.

Methods

Youths and adults with and without BD (N = 108, age range = 9.8-55.9 years) completed an emotional face labeling task during fMRI acquisition. We leveraged three different fMRI analytic tools to identify age-related neural mechanisms of BD, investigating (a) change in neural responses over the course of the task, (b) neural activation averaged across the entire task, and (c) amygdala functional connectivity.

Results

We found converging Age Group × Diagnosis patterns across all three analytic methods. Compared to healthy youths vs adults, youths vs adults with BD s

SUBMITTER: Kryza-Lacombe M 

PROVIDER: S-EPMC6597279 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature