Impact and Timing of Smoking Cessation on Reducing Risk of Rheumatoid Arthritis Among Women in the Nurses' Health Studies.

ABSTRACT:

Objective

To investigate the impact and timing of smoking cessation on developing rheumatoid arthritis (RA) and serologic phenotypes.

Methods

We investigated smoking cessation and RA risk in the Nurses' Health Study (NHS) (1976-2014) and the NHS II (1989-2015). Smoking exposures and covariates were obtained by biennial questionnaires. Self-reported RA was confirmed by medical record review for American College of Rheumatology/European League Against Rheumatism criteria. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for RA serologic phenotypes (all, seropositive, seronegative) according to smoking status, intensity, pack-years, and years since cessation.

Results

Among 230,732 women, we identified 1,528 incident cases of

SUBMITTER: Liu X 

PROVIDER: S-EPMC6597309 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature