The Correlation between IL-1β-C31T Gene Polymorphism and Susceptibility to Breast Cancer.

ABSTRACT:

Purpose

Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, has been shown to influence breast cancer susceptibility. The relationship between its risk of breast cancer and IL-1β-C31T polymorphism has been demonstrated, but the results remain controversial. Therefore, our study aimed to investigate the correlation between the IL-1β-C31T gene polymorphism and susceptibility to breast cancer.

Methods

The genotype frequencies of IL-1β-C31T polymorphism were compared between 204 breast cancer cases and 210 controls using polymerase chain reaction and restriction fragment length polymorphism techinques. Further multivariate binary logistic regression analyses were used to assess the association between IL-1β-C31T polymorphism and breast cancer ris

SUBMITTER: Eras N 

PROVIDER: S-EPMC6597413 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature