Synthetic scaffolds for musculoskeletal tissue engineering: cellular responses to fiber parameters.

ABSTRACT: Tissue engineering often uses synthetic scaffolds to direct cell responses during engineered tissue development. Since cells reside within specific niches of the extracellular matrix, it is important to understand how the matrix guides cell response and then incorporate this knowledge into scaffold design. The goal of this review is to review elements of cell-matrix interactions that are critical to informing and evaluating cellular response on synthetic scaffolds. Therefore, this review examines fibrous proteins of the extracellular matrix and their effects on cell behavior, followed by a discussion of the cellular responses elicited by fiber diameter, alignment, and scaffold porosity of two dimensional (2D) and three dimensional (3D) synthetic scaffolds. Variations in fiber diameter, ali

SUBMITTER: Jenkins TL 

PROVIDER: S-EPMC6597555 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature