LobSig is a multigene predictor of outcome in invasive lobular carcinoma.

ABSTRACT: Invasive lobular carcinoma (ILC) is the most common special type of breast cancer, and is characterized by functional loss of E-cadherin, resulting in cellular adhesion defects. ILC typically present as estrogen receptor positive, grade 2 breast cancers, with a good short-term prognosis. Several large-scale molecular profiling studies have now dissected the unique genomics of ILC. We have undertaken an integrative analysis of gene expression and DNA copy number to identify novel drivers and prognostic biomarkers, using in-house (n = 25), METABRIC (n = 125) and TCGA (n = 146) samples. Using in silico integrative analyses, a 194-gene set was derived that is highly prognostic in ILC (P = 1.20 × 10^-5)-we named this metagene 'LobSig'. Assessing a 10-year f

SUBMITTER: McCart Reed AE 

PROVIDER: S-EPMC6597578 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature