Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group.

ABSTRACT:

Introduction

Survivors of critical illness frequently exhibit acute and chronic neurological complications. The underlying aetiology of this dysfunction remains unknown but may be associated with cerebral ischaemia. This study will use near-infrared spectroscopy to non-invasively quantify regional cerebral oxygenation (rSO₂) to assess the association between poor rSO₂ during the first 72 hours of critical illness with delirium severity, as well as long-term sensorimotor and cognitive impairment among intensive care unit (ICU) survivors. Further, the physiological determinants of rSO₂ will be examined.

Methods and analysis

This multicentre prospective observational study will consider adult patients (≥18 years old) eligible for enrolment if wi

SUBMITTER: Wood MD 

PROVIDER: S-EPMC6597627 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature