The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study.

ABSTRACT:

Objective

To inform feasibility and design of a future randomised controlled trial (RCT) using brain functional MRI (fMRI) to determine the mechanism of action of gabapentin in managing chronic pelvic pain (CPP) in women.

Design

Mechanistic study embedded in pilot RCT.

Setting

University Hospital.

Participants

Twelve women (18-50 years) with CPP and no pelvic pathology (follow-up completed March 2014).

Intervention

Oral gabapentin (300-2700 mg) or matched placebo.

Outcome measures

After 12 weeks of treatment, participants underwent fMRI of the brain (Verio Siemens 3T MRI) during which noxious heat and punctate stimuli were delivered to the pelvis and arm. Outcome measures included pain (visual analogue scale), blood oxygen level dependent signal c

SUBMITTER: Seretny M 

PROVIDER: S-EPMC6597644 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature