ATM rs189037 significantly increases the risk of cancer in non-smokers rather than smokers: an updated meta-analysis.

ABSTRACT: Rs189037 (G>A) is an important functional variant with ataxia telangiectasia mutated (ATM) gene, which might affect ATM's expression involvement in several human cancers. Increasing evidence reveals that smoking-related cancers have distinct molecular characteristics from non-smoking cancers. Until now, the role of ATM rs189037 in cancer risk stratified by smoking status still remains unclear. To evaluate the association between ATM rs189037 and cancer risk based on smoking status, we performed this meta-analysis by a comprehensive literature search via databases of PubMed, Embase, Web of Science and CNKI, updated till January 2019. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were extracted from eligible studies if available

SUBMITTER: He X 

PROVIDER: S-EPMC6597848 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature