Investigation of leptin receptor rs1137101 G>A polymorphism with cancer risk: evidence from 35936 subjects.

ABSTRACT: Leptin receptor (LEPR) signaling may be involved in promoting angiogenesis and proliferation, inhibiting apoptosis and playing a vital role in the progression of carcinogenesis. A number of studies have focused on the association of LEPR rs1137101 variants with susceptibility of cancer, however, the observed results were controversial. We searched literature on the relationship of LEPR rs1137101 G>A polymorphism with cancer risk by using PubMed and Embase databases, covering all publications up to 14 October 2018. In total, 44 case-control studies with 35,936 subjects were included. After combining all eligible studies, we identified null relationship between LEPR gene rs1137101 G>A polymorphism and overall cancer risk [A vs. G: odds ratio (OR ) =  0.97, 95% con

SUBMITTER: Rong G 

PROVIDER: S-EPMC6597850 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature