Incomplete ART adherence is associated with higher inflammation in individuals who achieved virologic suppression in the START study.

ABSTRACT:

Introduction

Suboptimal ART adherence, despite HIV viral suppression, has been associated with chronic residual inflammation. Whether this association extends to individuals who initiate ART during early HIV infection remains unknown, which was the objective of this study.

Methods

Plasma levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein, serum amyloid A protein (SAA), IL-27, soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, D-dimer and the CD4+/CD8+ T-cell ratio, were analysed at baseline and eight months after ART initiation in treatment-naïve participants with HIV and CD4+ T-cells >500 cells/mm³ enrolled in the immediate arm of START. Adherence was assessed by seven-day self-report. Multivariable linear regression

SUBMITTER: Castillo-Mancilla JR 

PROVIDER: S-EPMC6597899 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature