Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.

ABSTRACT: There is tremendous interest in the role of the neuroimmune system and inflammatory processes in substance use disorders (SUDs). Imaging biomarkers of the neuroimmune system in vivo provide a vital translational bridge between preclinical and clinical research. Herein, we examine two imaging techniques that measure putative indices of the neuroimmune system and review their application among SUDs. Positron emission tomography (PET) imaging of 18 kDa translocator protein availability is a marker associated with microglia. Proton magnetic resonance spectroscopy quantification of myo-inositol levels is a putative glial marker found in astrocytes. Neuroinflammatory responses are initiated and maintained by microglia and astrocytes, and thus represent important imaging markers. The goal

SUBMITTER: Woodcock EA 

PROVIDER: S-EPMC6597912 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature