Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.

ABSTRACT: Periodontitis is a microbial-induced chronic inflammatory disease, which may not only result in tooth loss, but can also contribute to the development of various systemic diseases. The transition from healthy to diseased periodontium depends on microbial dysbiosis and impaired host immune response. Although periodontitis is a common disease as well as associated with various systemic inflammatory conditions, the taxonomic profiling of the salivary microbiota in periodontitis and its association with host immune and inflammatory mediators has not been reported. Therefore, the aim of this study was to identify key pathogens and their potential interaction with the host's inflammatory mediators in saliva samples for periodontitis risk assessment. The microbial 16S rRNA gene sequencing and the

SUBMITTER: Lundmark A 

PROVIDER: S-EPMC6598052 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature