Targeted Protein Internalization and Degradation by ENDosome TArgeting Chimeras (ENDTACs).

ABSTRACT: Targeted protein degradation has generated excitement in chemical biology and drug discovery throughout academia and industry. By hijacking the machinery responsible for protein degradation via the ubiquitin proteasome system (UPS), various cellular targets have been selectively degraded. However, since the tools used, often termed PROteolysis TArgeting Chimeras (PROTACs), hijack the intracellular quality control machinery, this technology can only access targets within the cell. Extracellular targets such as growth factors, cytokines, and chemokines bind to cell surface receptors, often initiating aberrant signaling in multiple diseases such as cancer and inflammation. However, efforts to develop small molecule inhibitors for these extracellular target proteins have been challenging. Here

SUBMITTER: Nalawansha DA 

PROVIDER: S-EPMC6598169 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature