Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes.

ABSTRACT:

Background

Hospital wastewaters contain fecal material from a large number of individuals, of which many are undergoing antibiotic therapy. It is, thus, plausible that hospital wastewaters could provide opportunities to find novel carbapenemases and other resistance genes not yet described in clinical strains. Our aim was therefore to investigate the microbiota and antibiotic resistome of hospital effluent collected from the city of Mumbai, India, with a special focus on identifying novel carbapenemases.

Results

Shotgun metagenomics revealed a total of 112 different mobile antibiotic resistance gene types, conferring resistance against almost all classes of antibiotics. Beta-lactamase genes, including encoding clinically important carbapenemases, such as NDM, VIM, IMP, KPC,

SUBMITTER: Marathe NP 

PROVIDER: S-EPMC6598227 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature