A kinetic metabolic study of lipid production in Chlorella protothecoides under heterotrophic condition.

ABSTRACT:

Background

Microalgae have been proposed as potential platform to produce lipid-derived products, such as biofuels. Knowledge on the intracellular carbon flow distribution may identify key metabolic processes during lipid synthesis thus refining culture/genetic strategies to maximize cell lipid productivity. A kinetic metabolic model simulating cell metabolic behavior and lipid production was first applied in the microalgae platform Chlorella protothecoides under heterotrophic condition. It combines both physiology and flux information in a kinetic approach. Cell nutrition, growth, lipid production and almost 30 metabolic intermediates covering central carbon metabolism were included and simulated.

Results

Model simulations were shown to adequately agree with experimental da

SUBMITTER: Ren X 

PROVIDER: S-EPMC6598345 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature