Placental microRNAs in pregnancies with early onset intrauterine growth restriction and preeclampsia: potential impact on gene expression and pathophysiology.

ABSTRACT:

Background

A normally developed placenta is integral to a successful pregnancy. Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two common pregnancy related complications that maybe a result of abnormal placental development. Placental microRNAs (miRNAs) have been investigated as potential biomarkers for these complications, as they may play a role in placental development and pathophysiology by influencing gene expression. The purpose of this study is to utilize next-generation sequencing to determine miRNA and gene expression in human placental (chorionic villous) samples from three distinct patient groups with early-onset (EO) PE, IUGR, or PE + IUGR.

Methods

Placental tissues were collected from four patient groups (control [N = 21], EO-PE [N = 20], EO-IU

SUBMITTER: Awamleh Z 

PROVIDER: S-EPMC6598374 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature