Recurrent MSC ^E116K mutations in ALK-negative anaplastic large cell lymphoma.

ABSTRACT: Anaplastic large cell lymphomas (ALCLs) represent a relatively common group of T-cell non-Hodgkin lymphomas (T-NHLs) that are unified by similar pathologic features but demonstrate marked genetic heterogeneity. ALCLs are broadly classified as being anaplastic lymphoma kinase (ALK)⁺ or ALK^-, based on the presence or absence of ALK rearrangements. Exome sequencing of 62 T-NHLs identified a previously unreported recurrent mutation in the musculin gene, MSC ^E116K, exclusively in ALK^- ALCLs. Additional sequencing for a total of 238 T-NHLs confirmed the specificity of MSC ^E116K for ALK^- ALCL and further demonstrated that 14 of 15 mutated cases (93%) had coexisting DUSP22 rearrangements. Musculin is a ba

SUBMITTER: Luchtel RA 

PROVIDER: S-EPMC6598380 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature