Positioning-Group-Enabled Biocatalytic Oxidative Dearomatization.

ABSTRACT: Biocatalysts have the potential to perform reactions with exceptional selectivity and high catalytic efficiency while utilizing safe and sustainable reagents. Despite these positive attributes, the utility of a biocatalyst can be limited by the breadth of substrates that can be accommodated in the active site in a reactive pose. Proven strategies exist for optimizing the performance of a biocatalyst toward unnatural substrates, including protein engineering; however, these methods can be time intensive and require specialized equipment that renders these approaches inaccessible to synthetic chemists. Strategies accessible to chemists for the expansion of a natural enzyme's substrate scope, while maintaining high levels of site- and stereoselectivity, remain elusive. Here, we employ a compu

SUBMITTER: Dockrey SAB 

PROVIDER: S-EPMC6598382 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature