Targeted Ganglionated Plexi Denervation Using Magnetic Nanoparticles Carrying Calcium Chloride Payload.

ABSTRACT:

Objectives

This study sought to develop a novel targeted delivery therapy to ablate the major atrial ganglionated plexi (GP) using magnetic nanoparticles carrying a CaCl₂ payload.

Background

Prior studies indicated the role of hyperactivity of the cardiac autonomic nervous system in the genesis of atrial fibrillation.

Methods

Twenty-eight male mongrel dogs underwent a bilateral thoracotomy. CaCl₂-encapsulated magnetic nanoparticles (Ca-MNP) included magnetite in a sphere of biocompatible, biodegradable poly(lactic-co-glycolic acid). A custom external electromagnet focusing the magnetic field gradient (2,600 G) on the epicardial surface of the targeted GP was used to pull Ca-MNP into and release CaCl₂ within the GP. The ventricular rate

SUBMITTER: Yu L 

PROVIDER: S-EPMC6598434 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature