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A ruthenium(ii)-catalyzed C-H allenylation-based approach to allenoic acids.

ABSTRACT: A Ru(ii)-catalyzed direct access to various functionalized allenoic acids via C-H allenylation of readily available aryl carboxylic acids with propargylic acetates is reported. Axially chiral allenoic acids could be obtained in high ee by using optically active propargylic acetates through a chirality transfer strategy.

SUBMITTER: Wu X

PROVIDER: S-EPMC6598647 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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A ruthenium(ii)-catalyzed C-H allenylation-based approach to allenoic acids.

Wu Xiaoyan X Fan Junjie J Fu Chunling C Ma Shengming S

Chemical science 20190510 25

A Ru(ii)-catalyzed direct access to various functionalized allenoic acids <i>via</i> C-H allenylation of readily available aryl carboxylic acids with propargylic acetates is reported. Axially chiral allenoic acids could be obtained in high ee by using optically active propargylic acetates through a chirality transfer strategy. ...[more]

PMID: 31341585

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