A prospective longitudinal brain morphometry study of children with sickle cell disease.

ABSTRACT:

Background and purpose

Age-related changes in brain morphology are crucial to understanding the neurobiology of sickle cell disease. We hypothesized that the growth trajectories for total GM volume, total WM volume, and regional GM volumes are altered in children with sickle cell disease compared with controls.

Materials and methods

We analyzed T1-weighted images of the brains of 28 children with sickle cell disease (mean baseline age, 98 months; female/male ratio, 15:13) and 28 healthy age- and sex-matched controls (mean baseline age, 99 months; female/male ratio, 16:12). The total number of MR imaging examinations was 141 (2-4 for each subject with sickle cell disease, 2-3 for each control subject). Total GM volume, total WM volume, and regional GM volumes were measured by

SUBMITTER: Chen R 

PROVIDER: S-EPMC6598682 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature