Transcriptional signature primes human oral mucosa for rapid wound healing.

ABSTRACT: Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We present a unique comparative analysis between human oral and cutaneous wound healing using paired and sequential biopsies during the repair process. Using molecular profiling, we determined that wound-activated transcriptional networks are present at basal state in the oral mucosa, priming the epithelium for wound repair. We show that oral mucosal wound-related networks control epithelial cell differentiation and regulate inflammatory responses, highlighting fundamental global mechanisms of repair and inflammatory responses in humans. The paired comparative analysis

SUBMITTER: Iglesias-Bartolome R 

PROVIDER: S-EPMC6598699 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature