Lower extremity muscle pathology in myotonic dystrophy type 1 assessed by quantitative MRI.

ABSTRACT:

Objective

To determine the value of quantitative MRI in providing imaging biomarkers for disease in 20 different upper and lower leg muscles of patients with myotonic dystrophy type 1 (DM1).

Methods

We acquired images covering these muscles in 33 genetically and clinically well-characterized patients with DM1 and 10 unaffected controls. MRIs were recorded with a Dixon method to determine muscle fat fraction, muscle volume, and contractile muscle volume, and a multi-echo spin-echo sequence was used to determine T2 water relaxation time (T2_water), reflecting putative edema.

Results

Muscles in patients with DM1 had higher fat fractions than muscles of controls (15.6 ± 11.1% vs 3.7 ± 1.5%). In addition, patients had smaller muscle volumes (902 ± 232 vs 1,097 ±

SUBMITTER: Heskamp L 

PROVIDER: S-EPMC6598795 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature