Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline.

ABSTRACT:

Objective

To test whether targeting hippocampal-cortical brain networks with high-frequency transcranial magnetic stimulation in older adults influences behavioral and neural measures characteristic of age-related memory impairment.

Methods

Fifteen adults aged 64 to 80 years (mean = 72 years) completed a single-blind, sham-controlled experiment. Stimulation targets in parietal cortex were determined based on fMRI connectivity with the hippocampus. Recollection and recognition memory were assessed after 5 consecutive daily sessions of full-intensity stimulation vs low-intensity sham stimulation using a within-subjects crossover design. Neural correlates of recollection and recognition memory formation were obtained via fMRI, measured within the targeted hippocampal-cortical n

SUBMITTER: Nilakantan AS 

PROVIDER: S-EPMC6598819 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature