Global gene expression profiles from PBMCs treated with reference tobacco product preparations.

ABSTRACT: This Data in Brief article describes global gene expression profiles from human peripheral blood mononuclear cells (PBMCs) that were treated with preparations from reference combustible and non-combustible tobacco products (TPPs). PBMCs isolated from non-smokers were treated with three non-cytotoxic doses of aqueous preparations from 3R4F cigarettes, termed Whole Smoke-Conditioned Medium (WS-CM) and a single dose of 2S3 moist snuff, termed smokeless tobacco extract (STE). PBMCs were treated with the test articles for 3 hours and the extracted total RNA was reverse transcribed and hybridized to HTA 2.0 Genechip^® arrays and scanned using an Affymetrix GeneChip^® Scanner 3000. CEL files and CHP files were generated using an Affymetrix Expression console. The CEL files wer

SUBMITTER: Arimilli S 

PROVIDER: S-EPMC6598865 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature