Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam.

ABSTRACT: Dengue pathogenesis is extremely complex. Dengue infections are thought to induce life-long immunity from homologous challenges as well as a multi-factorial heterologous risk enhancement. Here, we use the data collected from a prospective cohort study of dengue infections in schoolchildren in Vietnam to disentangle how serotype interactions modulate clinical disease risk in the year following serum collection. We use multinomial logistic regression to correlate the yearly neutralizing antibody measurements obtained with each infecting serotype in all dengue clinical cases collected over the course of 6 years (2004-2009). This allowed us to extrapolate a fully discretised matrix of serotype interactions, revealing clear signals of increased risk of clinical illness in individuals primed wit

SUBMITTER: Aguas R 

PROVIDER: S-EPMC6598999 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature