Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

ABSTRACT: Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune signatures are dominated by either IFN-γ and IFN-inducible, IL-17-induced neutrophil- or allergy-associated gene expression. Type I IFN and IFN-γ-inducible, but not IL-17- or allergy-associated signatures, are preserved in the blood. While IL-17-associated genes identified in lung are detected in blood, the allergy signature is only detectable in blood CD4⁺ effector cells. Type I IFN-inducible genes are abrogated in the absence of IFN-γ signaling and decrease in the abs

SUBMITTER: Singhania A 

PROVIDER: S-EPMC6599044 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature