Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants.

ABSTRACT:

Objectives

This study tested the hypothesis that longer duration of any type of respiratory support is associated with an increased rate of death or neurodevelopmental impairment (NDI) at 18-22 months.

Methods

Retrospective cohort study using the Generic Database of NICHD Neonatal Research Network from 2006 to 2010. Infants were born at <27 weeks gestational age with birth weights of 401-1000 g. Respiratory support received during initial hospitalization from birth was characterized as follows: no support, only invasive support, only non-invasive support or mixed invasive, and non-invasive support. The primary outcome was death after 24 h of life or NDI at 18-22 months corrected age.

Results

In a cohort of 3651 infants, 1494 (40.9%) died or had NDI. Cumulative respira

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6599180 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature