From genomic to LC-MS/MS evidence: Analysis of PfEMP1 in Benin malaria cases.

ABSTRACT: BACKGROUND:PfEMP1 is the major protein from parasitic origin involved in the pathophysiology of severe malaria, and PfEMP1 domain subtypes are associated with the infection outcome. In addition, PfEMP1 variability is endless and current publicly available protein repositories do not reflect the high diversity of the sequences of PfEMP1 proteins. The identification of PfEMP1 protein sequences expressed with samples remains challenging. The aim of our study is to identify the different PfEMP1 proteins variants expressed within patient samples, and therefore identify PfEMP1 proteins domains expressed by patients presenting uncomplicated malaria or severe malaria in malaria endemic setting in Cotonou, Benin. METHODS:We performed a multi-omic approach to decipher PfEMP1 expression at the patien

SUBMITTER: Kamaliddin C 

PROVIDER: S-EPMC6599223 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature